4-Methylpentanoic acid


CAS No. : 646-07-1

(Synonyms: Isocaproic acid)

646-07-1
Price and Availability of CAS No. : 646-07-1
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Cat. No. : HY-W015882
M.Wt: 116.16
Formula: C6H12O2
Purity: >98 %
Solubility: DMSO : 100 mg/mL (ultrasonic)
Introduction of 646-07-1 :

4-Methylpentanoic acid (Isocaproic Acid) is a short-chain fatty acid and a metabolite of 20 α-hydroxycholesterol (HY-12316) that can be detected in feces. The concentration of 4-Methylpentanoic acid is closely associated with several diseases, such as depression. 4-Methylpentanoic acid is also applicable to studies on cholesterol metabolism[1][2].
In Vitro:4-Methylpentanoic acid (200 μg (carrier added post-incubation); 3 h) produced by incubation of 20α-hydroxycholesterol-22-14C with bovine adrenal homogenate supernatant, with yields of 17% and 20% in two separate experiments, confirming it as a metabolite in the cholesterol degradation pathway[2]. In Vivo:4-Methylpentanoic acid (500-2000 mg/kg; p.o.; single administration; 10-250 mg/kg/day; p.o.; daily administration; 41-53 days) shows no clastogenic activity in mice and rats[1].

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