Scoulerine
CAS No. : 6451-73-6
(Synonyms: (-)-Scoulerine; Discretamine)
| Size | Price | Stock |
|---|---|---|
| 1mg | $55 | In-stock |
| 5mg | $200 | In-stock |
| 10mg | $350 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-N1255 |
| M.Wt: | 327.37 |
| Formula: | C19H21NO4 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Scoulerine ((-)-Scoulerine), an isoquinoline alkaloid, is a potent antimitotic compound. Scoulerine is also an inhibitor of BACE1 (?-site amyloid precursor protein cleaving enzyme 1). Scoulerine inhibits proliferation, arrests cell cycle, and induces apoptosis in cancer cells[1].
In Vitro: Scoulerine ((-)-Scoulerine) inhibits mini-panel of human leukemic cells, MOLT-4 (WT), Jurkat (TP53 mutated), Raji (TP53 mutated), HL-60 (TP53 null), U-937 (TP53 mutated), and HEL 92.1.7 (wild-type), with IC50s ranging from 2.7?μM to 6.5?μM[1].
Scoulerine (2.5-20?μM; 24 hours) decreases proliferation of Jurkat and MOLT-4 cells[1].
Scoulerine (2.5-20?μM; 24 hours) induces MOLT-4 and Jurkat cells apoptosis[1].
Scoulerine induces G2 or M cell cycle arrest[1].
Scoulerine (2.5-5?μM; 24?hours) shows an upregulation of p53 protein in p53 wild-type MOLT-4 cells[1].
Scoulerine (2.5-5?μM; 24-48 hours) activates caspase-3/7, -8 and -9 in a dose-dependent manner[1].
Scoulerine (5-10 μM; 24 hours) disrupts microtubule structure of A549 lung carcinoma cells[1]
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