Glycoursodeoxycholic acid
CAS No. : 64480-66-6
(Synonyms: GUDCA; Ursodeoxycholylglycine)
| Size | Price | Stock |
|---|---|---|
| 250mg | $50 | In-stock |
| 1g | $119 | In-stock |
| 5g | $417 | In-stock |
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| Cat. No. : | HY-N1424 |
| M.Wt: | 449.62 |
| Formula: | C26H43NO5 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Glycoursodeoxycholic acid, a acyl glycine and a bile acid-glycine conjugate, is a metabolite of ursodeoxycholic acid. In Vitro: The antioxidant compound glycoursodeoxycholic acid (GUDCA) fully abrogates UCB-induced cytochrome c oxidase inhibition and significantly prevents oxidative stress, metabolic alterations, and cell demise[1].GUDCA has shown therapeutic efficacy in neurodegenerative models and diseases. Increased cytosolic SOD1 inclusions were observed in 4 DIV NSC-34/hSOD1(G93A) cells together with decreased mitochondria viability, caspase-9 activation, and apoptosis[2]. Glycoursodeoxycholic acid shows preventive and restorative effects against unconjugated bilirubin -induced blood-brain barrier disruption and damage to human brain microvascular endothelial cells[3].
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