Dulcoside A
CAS No. : 64432-06-0
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| Cat. No. : | HY-N6992 |
| M.Wt: | 788.87 |
| Formula: | C38H60O17 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Dulcoside A is a glycoside that can be isolated from Stevia rebaudiana that elicits sweet and bitter taste through activation of TAS1R. Dulcoside A also exhibits anti-inflammatory activity[1][2].
In Vitro:Dulcoside A produces sweetness by activating sweet taste receptors hTAS1R2/hTAS1R3 with a sweet taste threshold of 32.9 μM. Dulcoside A also activates bitter taste receptors hTAS2R4 and hTAS2R14, thereby producing bitter taste with a sweet taste threshold of 49 μM. Dulcoside A activates the hTAS1R2/hTAS1R3, hTAS2R4 and hTAS2R14 with the threshold concentrations of 38.8 μM, 200 μM and 50 μM[1].
In Vivo:Dulcoside A inhibits TPA (HY-18739)-induced inflammation with a LD50 of 92.5 μg/ear (0.12 μM/ear) in mouse ear edema model[2].
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