Tetrahydropapaverine (hydrochloride)
CAS No. : 6429-04-5
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|---|---|---|
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| 50mg | $60 | In-stock |
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| Cat. No. : | HY-N0137 |
| M.Wt: | 379.88 |
| Formula: | C20H26ClNO4 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic);H2O : ≥ 100 mg/mL |
Tetrahydropapaverine hydrochloride is a tetrahydroisoquinoline (TIQ) compound with inhibitory effects on tryptophan hydroxylase (TPH) (IC50 = 5.7 μM). Tetrahydropapaverine hydrochloride decreases intracellular serotonin content in murine mastocytoma P815 cells, with an IC50 value of 6.2 μM. Tetrahydropapaverine hydrochloride can be used for studies on potential neurotoxicity in monoaminergic neurons[1][2].
In Vitro:Tetrahydropapaverine (2.5-10 μM, 24 h) hydrochloride concentration-dependently decreases intracellular serotonin content in P815 cells, with an IC50 value of 6.2 μM[1].
Tetrahydropapaverine (5-20 μM, 24 h) hydrochloride significantly inhibits intracellular tryptophan hydroxylase (TPH) activity in P815 cells with an IC50 value of 5.7 μM[1].
In Vivo:Tetrahydropapaverine (10 mg/kg, intracerebral injection, 7 days) hydrochloride causes significant reduction of striatal dopamine in Sprague-Dawley rats[2].
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