L189
CAS No. : 64232-83-3
| Size | Price | Stock |
|---|---|---|
| 5mg | $74 | In-stock |
| 10mg | $119 | In-stock |
| 25mg | $245 | In-stock |
| 50mg | $428 | In-stock |
| 100 mg | Get quote | |
| 200 mg | Get quote | |
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| Cat. No. : | HY-15588 |
| M.Wt: | 246.29 |
| Formula: | C11H10N4OS |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 33 mg/mL |
L189 is a DNA ligase inhibitor. L189 has inhibition effect for DNA Ligase I, III and IV with IC50 values of 5 μM, 9 μM and 5 μM, respectively. L189 has no cytotoxicity and individually increase cell death. L189 can be used for the research of cancer[1][2].
In Vitro: L189 inhibits DNA Ligase I, III and IV activity with IC50 values of 5 μM, 9 μM and 5 μM, respectively[1].
L189 (5 μM, 48 h) bring good anti-proliferation activity preferentially and cause cell death by creating a cytotoxic environment[2].
L189 (5 μM, 48 h) reduces HeLa nuclear staining along with TMZ[2].
L189 (5 μM, 48 h) enhances TMZ-induced HeLa growth arrest when along with TMZ that possibly in G2/M cell cycle phase without employing cell death mechanisms[2].
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