Atracurium
CAS No. : 64228-79-1
(Synonyms: BW-33A (free acid))
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| Cat. No. : | HY-B0292 |
| M.Wt: | 929.14 |
| Formula: | C53H72N2O12+2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
tracurium (BW-33A free acid) is a potent, competitive and non-depolarizing neuromuscular blocking agent.Atracurium also is an AChR receptor antagonist. Atracurium induces bronchoconstriction and neuromuscular blockade. Atracurium promotes astroglial differentiation[1][2][3][4][5].
In Vitro: Atracurium (10 µM; 72 h) promotes astroglial but not neuronal differentiation in HSR040622 and HSR040821 cells[4].
Atracurium (10 µM; 48 h) reduces tumor engraftment and increases survival of mice xenotransplanted with ex-vivo treated GSCs[4].
Atracurium (2.4 µM; 120 min) induces a complete fade of the tetanic contraction while only slightly affected the twitch in rat extensor digitorum longus muscle cells[5].
In Vivo: Atracurium (1, 5, 10, 20, 50 mg/kg; i.v.) induces bronchoconstriction in DBA/2 and SJL mice[2].
Atracurium (4.8 mg/kg; i.v.) induces neuromuscular blockade in rats[3].
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