Plaunotol

Plaunotol is an orally active acyclic diterpene alcohol. Plaunotol has antibacterial activity against Helicobacter pylori which causes peptic ulcer ^[1]. Plaunotol inhibits tumor angiogenesis and cell proliferation. Plaunotol induces apoptosis by activation of caspase 8 and caspase 9 pathways. Plaunotol is a potential anticancer agent against colon cancer ^[2]. In Vitro:Plaunotol (0, 10, 20, or 40 μM, 24 or 48 h) shows a significant inhibition of cell proliferation in human colon cancer cell line DLD1^[2].
Plaunotol (40 μM, 24 or 48 h) induces apoptosis in human colon cancer cell line DLD1^[2].
Plaunotol (0, 10, 20, or 40 μM, 48 h) causes activation of caspase-3 in human colon cancer cell line DLD1^[2]. In Vivo:Plaunotol (10, 25 or 50 mg/kg, orally, for 3 h) significantly alleviates gastric mucosal damage in male Wistar rats treated with C48/80 ^[3].
Plaunotol (10, 25 or 50 mg/kg, orally, for 3 h) does not affect serum serotonin and histamine concentrations or gastric mucosal blood flow in male Wistar rats treated with C48/80 ^[3].
Plaunotol (10, 25 or 50 mg/kg, orally, 3 h) significantly decreases the activity of myeloperoxidase (MPO) and the content of lipid peroxidase thiobarbituric acid reactive substance (TBARS) of gastric mucosa in male Wistar rats treated with C48/80^[3].