Oxiconazole nitrate


CAS No. : 64211-46-7

(Synonyms: Ro 13-8996)

64211-46-7
Price and Availability of CAS No. : 64211-46-7
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10mg $72 In-stock
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Cat. No. : HY-B1324
M.Wt: 492.14
Formula: C18H14Cl4N4O4
Purity: >98 %
Solubility: DMSO : ≥ 100 mg/mL
Introduction of 64211-46-7 :

Oxiconazole (Ro 13-8996) nitrate is a broad spectrum anti-fungal agent which can inhibit the growth of Candida, Aspergillus and Trichophyton. Oxiconazole nitrate is also a highly efficacious activator of CYP3A4 transactivation, which could be antagonized by Rifampicin (HY-B0272) in a competitive manner. Oxiconazole nitrate exhibits inhibitory effect against colorectal cancer (CRC) via peroxiredoxin-2 (PRDX2)-mediated autophagy arrest[1][2][3]. IC50 & Target: MIC90: 0.25 μg/mL (T. tonsurans), 0.5 μg/mL (T. rubrum)[1] In Vitro: Oxiconazole (24 h; 0-40 μM) inhibits CRC cell growth[3].
Oxiconazole has antifungal activity against Candida, Aspergillus and Trichophyton[1].
Antifungal Activities of Oxiconazole[1].
Candida
albicans
Candida
glabrata
Candida
parapsilosis
Aspergillus
fumigatus
Aspergillus
flavus
Trichophyton
mentagrophytes
Trichophyton
rubrum
Oxiconazole 0.03 μg/mL 0.01 μg/mL 0.008 μg/mL 2 μg/mL 2 μg/mL 2 μg/mL 2 μg/mL
In Vivo: Oxiconazole (50 mg/kg/day; IP; for 12 days) significantly restrains CRC cell growth[3].

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