BRD6989
CAS No. : 642008-81-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $80 | In-stock |
| 10mg | $120 | In-stock |
| 25mg | $240 | In-stock |
| 50mg | $360 | In-stock |
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| 200 mg | Get quote | |
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| Cat. No. : | HY-122586 |
| M.Wt: | 264.33 |
| Formula: | C16H16N4 |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic) |
BRD6989, an analog of the natural product cortistatin A (dCA), inhibits CDK8 and upregulates IL-10. BRD6989 selectively binds a complex of CDK8 with an IC50 of ~200 nM. BRD6989 inhibits the kinase activity of recombinant CDK8 or CDK19 complexes[1].
In Vitro:Pretreatment of BMDCs with BRD6989 (0-100 μM; for 48 hours) increases IL-10 production with an EC50 of ~1 μM[1].
BRD6989 (0.6, 1.7, 5, 15 μM) suppresses phosphorylation of the STAT1 transactivation domain at Ser727 in IFNγ-stimulated BMDCs[1].
BRD6989 (5 µM; ~2 hours) suppresses induction of STAT1–STAT2 activity and NF-κB activation to a varying degree after stimulation of BMDMs[1].
BRD6989 (5 µM; 24 hours) enhances IL-10 production in activated human and murine macrophages and dendritic cells[1].
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