4'-Hydroxy diclofenac
CAS No. : 64118-84-9
| Size | Price | Stock |
|---|---|---|
| 1mg | $240 | In-stock |
| 5mg | $550 | In-stock |
| 10mg | $880 | In-stock |
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| Cat. No. : | HY-15550 |
| M.Wt: | 312.15 |
| Formula: | C14H11Cl2NO3 |
| Purity: | >98 % |
| Solubility: | DMSO : 10 mg/mL (ultrasonic;warming;heat to 60°C) |
4'-Hydroxy diclofenac is an orally active metabolite of Diclofenac (HY-15036) by cytochrome P450 2C9 (CYP2C9). 4'-Hydroxy diclofenac has anti-inflammatory and analgesic properties[1][2].
In Vivo: A single oral administration of Diclofenac to humanized mice, the unchanged drug in plasma peaks at 0.25 hour and then declines with a half-life (t1/2) of 2.4 hours. 4'-Hydroxy diclofenac also peaks at 0.25 hour and is undetectable within 24 hours. The plasma concentration of unchanged 4'-Hydroxy diclofenac peaks at 0.25 hour and declines rapidly in Humanized chimeric mice received of 4'-Hydroxy diclofenac (10 mg/kg; a single oral)[2].
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- 4'-Hydroxy diclofenac
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