Valopicitabine
CAS No. : 640281-90-9
(Synonyms: NM283)
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| Cat. No. : | HY-108060 |
| M.Wt: | 356.37 |
| Formula: | C15H24N4O6 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Valopicitabine (NM283) is a nucleoside analog and the orally bioavailable proagent of the potent anti-HCV agent 2'-C-methylcytidine (NM107). NM107competitively inhibits NS5B polymerase, causing chain termination[1][2]. IC50 & Target:HCV[1] In Vivo: Valopicitabine (NM283) (100 mg/kg; oral administration; Sprague-Dawley Rats) shows the Cmax, AUC, t1/2, and tmax were 3.624 μg/mL, 8.95 μg h/mL, 0.64 hours and 1 hour, respectively[2].
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