MK-212
CAS No. : 64022-27-1
(Synonyms: CPP)
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| Cat. No. : | HY-101324 |
| M.Wt: | 198.65 |
| Formula: | C8H11ClN4 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
MK-212 (CPP) is an orally active, blood-brain barrier permeable agonist of 5-HT1C, 5-HT2 and 5-HT1A receptors. MK-212 induces hyperthermia, nausea, arousal, irritability and restlessness, inhibits the elevation of plasma cortisol and prolactin, and reduces feelings of calmness and overall positive affect. MK-212 mediates anxiety-like behaviors and motor inhibition. MK-212 is applicable to research related to schizophrenia and anxiety disorders[1][2]. In Vivo:MK-212 (1-4 mg/kg, i.p.; single administration) induces anxiogenic-like effects in rats in the elevated plus maze test, and the 4.0 mg/kg dose also produces motor inhibitory effects and exerts hypoactivity in the open field test[2].
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