Traumatic Acid

Traumatic Acid is a wound healing agent and a cytokinin (phytohormone). Traumatic Acid enhances the biosynthesis of collagen in cultured human skin fibroblasts. Traumatic Acid inhibits MCF-7 breast cancer cells viability and enhances apoptosis and oxidative stress. Traumatic Acid can be used in studies of cancer, circulatory disorders (including arterial hypertension), and skin diseases associated with oxidative stress and impaired collagen biosynthesis^[1][2]. IC50 & Target:IC50: collagen biosynthesis^[1] In Vitro: Traumatic Acid (0.1, 1 µM; 5 days) significantly increases cell number in fibroblasts^[1].
Traumatic Acid (0.1, 1 µM; 5 days) increases content of GPX activity and reduced glutathione, as well as decreases membrane phospholipid peroxidation in fibroblasts^[1].
Traumatic Acid (0.1, 1 µM; 5 days) enhances the production and secretion of medium collagen in medium of fibroblasts^[1].
Traumatic Acid (100, 200, 400, 600 µM; 48 h) significantly decreases live cell number, especially after 48h treatment at 100µM and 200µM in MCF-7 cells^[2].
Traumatic Acid (50-600 µM; 24, 48 h) causes dose-and time-dependent reduction in cell viability and induces apoptosis in MCF-7 cells^[2].
Traumatic Acid (50-200 µM; 24, 48 h) results in an oxidative damage of protein in MCF-7 cells^[2].
Traumatic Acid (100, 200 µM; 24, 48 h) efficiently enhances oxidative stress level in MCF-7 cells^[2].