Pildralazine
CAS No. : 64000-73-3
(Synonyms: Propyldazine)
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| Cat. No. : | HY-106471 |
| M.Wt: | 197.24 |
| Formula: | C8H15N5O |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Pildralazine (Propyldazine) is a hydralazinelike antihypertensive vasodilator containing a free hydrazine group. Pildralazine is orally active, has no significant carcinogenicity in mice model[1][2].
In Vivo:Pildralazine (6-43 mg/kg; p.o.; once daily) shows no significant carcinogenicity in B6C3F1 and BALB/c mice under a long-term bioassay and a transplacental-infantile bioassay[1].
Pildralazine and Hydralazine (HY-B0464A) act on a common receptor,sensitive to endogenous ATP and adenosine in the isolated tail artery from normotensive Wistar (NW) rats[2].
Pildralazine (1 mg/kg; p.o.; ) significantly inhibits the onset of severe hypertension in spontaneously hypertensive rats (SHR) model[3].
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