Tolbutamide
CAS No. : 64-77-7
| Size | Price | Stock |
|---|---|---|
| 25g | $38 | In-stock |
| 100g | $125 | In-stock |
| 500g | $560 | In-stock |
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| Cat. No. : | HY-B0401 |
| M.Wt: | 270.35 |
| Formula: | C12H18N2O3S |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 34 mg/mL |
Tolbutamide is an orally active KATP inhibitor. Tolbutamide inhibits cell proliferation, stimulates exocytosis of glucagon and reduces fetal lethality of mice. Tolbutamide can be used in the research of diabete[1][2][3][4].
In Vitro:Tolbutamide (400 μM, 24h) with dbcAMP reduces glioma cell proliferation by increasing connexin43 (Cx43)[1].
Tolbutamide (0.1 μM, 1 min) stimulates exocytosis by activation of a mitochondriallike KATP channel in rat A-cells[2].
In Vivo:Tolbutamide (125 mg/kg, Supplemented in daily diet for 27 weeks) reduces the incidence of diabetes mellitus in the non-obese-diabetic mouse[3].
Tolbutamide (100-400 mg/kg, Intraperitoneal injection, 400 mg/kg on day 13; 100 mg/kg on day 10-13; combined treatment: 100 mg/kg on day 10-12 and 400 mg/kg on day 13) reduces fetal lethality in pregnant mice[4].
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