Tetracycline (hydrochloride)

Tetracycline hydrochloride is a broad-spectrum antibiotic with oral activity. Tetracycline hydrochloride exhibits activity against a wide range of bacteria including gram-positive, gram-negative bacteria, chlamydiae, mycoplasmas and rickettsiae. Tetracycline hydrochloride can be used for the research of infections^[1]. In Vitro:Tetracycline hydrochloride shows susceptibilfty of V. vulnlflcus strain B3547 with MIC value of 0.5 g/mL^[2].
Tetracycline hydrochloride inhibits the L-amyloid aggregates formation and disassembles the pre-formed fibrils^[3]. In Vivo:Note:
Please do not refer to only one article to determine the experimental conditions. It is recommended to determine the optimal experimental conditions (animal strain, age, dosage, frequency and cycle, detection time and indicators, etc.) through preliminary experiments before the formal experiment.

Tetracycline can be used in animal modeling to create genetically engineered disease models. The pharmacokinetics of Tetracycline after intraperitoneal administration in broiler chickens exhibit unique distribution and elimination characteristics. Tetracycline distributes widely in the body, with rapid elimination, high clearance, and a large volume of distribution. After oral administration, Tetracycline shows high gastrointestinal absorption and moderate elimination rates. Although the absorption rate of Tetracycline is higher than that of most other tetracycline drugs, its overall drug exposure is relatively low^[4].