| Size | Price | Stock |
|---|---|---|
| 100mg | $42 | In-stock |
| 250mg | $56 | In-stock |
| 1g | $80 | In-stock |
| 5g | $204 | In-stock |
| 25g | $731 | In-stock |
| 50 g | Get quote | |
| 100 g | Get quote | |
| We match the lowest price on market. | ||
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| Cat. No. : | HY-17560 |
| M.Wt: | 501.31 |
| Formula: | C21H22Cl2N2O8 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic);H2O : 33.33 mg/mL (ultrasonic) |
Demeclocycline hydrochloride is an orally active tetracycline antibiotic that inhibits the binding of aminoacyl tRNA by binding to the 30S ribosomal subunit, thereby affecting protein synthesis. Demeclocycline hydrochloride exhibits antibacterial activity against a broad spectrum of bacterial infections[1][2].
In Vitro:Demeclocycline (0-100 μM; 24 h) hydrochloride treatment reduces AQP2 abundance in mpkCCD cells[3].
Demeclocycline (10 μM; 24 h) hydrochloride treatment promotes the activity of monocytes and macrophages[4].
Demeclocycline (1-10 μM; 72 h) hydrochloride treatment directly affects the growth of brain tumorinitiating cells[4].
In Vivo:Demeclocycline (Intraperitoneal injection; 40 mg/kg; once daily; 48 h) hydrochloride treatment results in a significant reduction of hyponatremia and a significant correction of the hypoosmolality, and is not nephrotoxic[3].
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