Demeclocycline (hydrochloride)


CAS No. : 64-73-3

64-73-3
Price and Availability of CAS No. : 64-73-3
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100mg $42 In-stock
250mg $56 In-stock
1g $80 In-stock
5g $204 In-stock
25g $731 In-stock
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Cat. No. : HY-17560
M.Wt: 501.31
Formula: C21H22Cl2N2O8
Purity: >98 %
Solubility: DMSO : 100 mg/mL (ultrasonic);H2O : 33.33 mg/mL (ultrasonic)
Introduction of 64-73-3 :

Demeclocycline hydrochloride is an orally active tetracycline antibiotic that inhibits the binding of aminoacyl tRNA by binding to the 30S ribosomal subunit, thereby affecting protein synthesis. Demeclocycline hydrochloride exhibits antibacterial activity against a broad spectrum of bacterial infections[1][2]. In Vitro:Demeclocycline (0-100 μM; 24 h) hydrochloride treatment reduces AQP2 abundance in mpkCCD cells[3].
Demeclocycline (10 μM; 24 h) hydrochloride treatment promotes the activity of monocytes and macrophages[4].
Demeclocycline (1-10 μM; 72 h) hydrochloride treatment directly affects the growth of brain tumorinitiating cells[4]. In Vivo:Demeclocycline (Intraperitoneal injection; 40 mg/kg; once daily; 48 h) hydrochloride treatment results in a significant reduction of hyponatremia and a significant correction of the hypoosmolality, and is not nephrotoxic[3].

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