Physostigmine (hemisulfate)
CAS No. : 64-47-1
(Synonyms: Eserine (hemisulfate))
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| Cat. No. : | HY-N2320 |
| M.Wt: | 324.38 |
| Formula: | C15H21N3O2.1/2H2O4S |
| Purity: | >98 % |
| Solubility: | H2O : 50 mg/mL (ultrasonic) |
Physostigmine hemisulfate (Eserine hemisulfate) is a reversible acetylcholinesterase (AChE) inhibitor. Physostigmine hemisulfate can crosses the blood-brain barrier and stimulates central cholinergic neurotransmission. Physostigmine hemisulfate can reverse memory deficits in transgenic mice with Alzheimer's disease. Physostigmine hemisulfate is also an antidote for anticholinergic poisoning[1][2][3][4].
In Vivo: Physostigmine hemisulfate (Eserine hemisulfate; 0.03-0.3 mg/kg; s.c.; daily for 6 weeks) improves deficits in contextual and cued memory in Tg(+) mice[2].
Physostigmine hemisulfate (IV; 0.1, 0.2 mg/kg) delays time to emergence from isoflurane anesthesia at doses ≥0.2 mg/kg in male Sprague-Dawley rats[4].
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