BMS-605541
CAS No. : 639858-32-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $95 | In-stock |
| 10mg | $150 | In-stock |
| 25mg | $320 | In-stock |
| 50mg | $520 | In-stock |
| 100mg | $830 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-120640 |
| M.Wt: | 401.43 |
| Formula: | C19H17F2N5OS |
| Purity: | >98 % |
| Solubility: | DMSO : 33.33 mg/mL (ultrasonic;warming;heat to 60°C) |
BMS-605541 is a selective and orally active inhibitor of VEGFR-2 kinase with an IC50 value of 23 nM and Ki value of 49 nM. BMS-605541 inhibits the activity of Flk-1, VEGFR-1 and PDGFR-β with IC50 values of 40 nM, 400 nM and 200 nM, respectively. BMS-605541 can be used for cancer research[1].
In Vitro:BMS-605541 (Compound 14) inhibits the growth of HUVECs through VEGF with an IC50 value of 25 nM[1].
In Vivo:BMS-605541 (12.5-180 mg/kg; once a day or twice a day for 14 days) has anti-tumor activity in thymic mice subcutaneously implanted with L2987 and HCT-116 xenografts[1].
Pharmacokinetic (PK) parameters of BMS-605541[1]
| Species | Administration manner | Dose (mg/kg) | Cmax (µM) | Tmax (h) | AUC (µM•h) | T1/2 (h) | MRT (h) | Cl (mL/min•kg) | Vss (L/kg) | Fpo (%) |
| Mouse | Oral gavage | 90 | 148 | 0.5 | 649 (0-24 h) | 1.7 | 3.4 | 100 | ||
| Mouse | Intravenous injection | 10 | 11.8 | 1.7 | 100 | |||||
| Rat | Oral gavage | 50 | 44.0 | 2.0 | 202 | 2.2 | 3.5 | 100 | ||
| Rat | Intravenous injection | 10 | 13.6 | 1.1 | 100 | |||||
| Cyno | Oral gavage | 5 | 8.0 | 0.75 | 28.5 | 7.1 | 7.9 | 52 | ||
| Cyno | Intravenous injection | 1 | 3.9 | 1.6 | 52 |
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