Bradanicline
CAS No. : 639489-84-2
(Synonyms: TC-5619)
| Size | Price | Stock |
|---|---|---|
| 5mg | $260 | In-stock |
| 10mg | $390 | In-stock |
| 25mg | $700 | In-stock |
| 50mg | $1050 | In-stock |
| 100mg | $1600 | In-stock |
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| Cat. No. : | HY-18060 |
| M.Wt: | 361.44 |
| Formula: | C22H23N3O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic;warming;heat to 60°C) |
Bradanicline is a highly selective α7 nicotinic acetylcholine receptor (nAChR) agonist (humanα7 nAChR: EC50=17 nM; Ki= 1.4 nM). Bradanicline is used for the research of cognitive disorders[1][2]. In Vitro: Bradanicline is more than a thousand-fold separation between the affinities for the α7 and α4β2 receptor subtypes and has no detectable effects on muscle or ganglionic nicotinic receptor subtypes, indicating a marked selectivity for the central nervous system over the peripheral nervous system[1]. In Vivo: Bradanicline (0.1-1 mg/kg) shows efficacy in animal models of the positive and negative symptoms and cognitive dysfunction of schizophrenia[2].
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