β-Amyrone

β-Amyrone (β-Amyron) is a triterpene compound which has anti-inflammatory activity through inhibiting the expression of COX-2. β-Amyrone has antifungal activity , as well as antiviral activity against Chikungunya virus. β-Amyrone also inhibits α-glucosidase and acetylcholinesterase (AChE) activity. β-Amyrone can be used in the research of disease like inflammation, infection, and obesity^[1][2][3][4]. IC50 & Target: PI3K-Akt signaling pathway^[3]; AChE inhibitor^[4]. In Vitro: β-Amyrone (1.25-10 μg/mL, 24 h) inhibits on NO^? production in LPS-stimulated J774 cells, with an IC₅₀ value of 4.61 μg/mL, and has no obvious effect on cell viability^[1].
β-Amyrone (10 μg/mL, 24 h) inhibits IL-6, IL-10 levels, and COX-2 expression in LPS-stimulated J774 cells^[1].
β-Amyrone (0-235 μM, 7days) has antiviral activity in Vero cells against Chikungunya virus (CHIKV), with EC₅₀ value of 86 uM^[2].
β-Amyrone inhibits α-glucosidase, acetylcholinesterase (AChE) and fungal activity with IC₅₀ values of 25 μM, 23 μM and 8 μg/mL, respectively^[4].
In Vivo: β-Amyrone (local administration on ear, 0.1-0.6 mg/kg, a single dose) inhibits ear edema formation in phenol-induced edema mice^[1].