Cyclosporin D
CAS No. : 63775-96-2
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|---|---|---|
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| 10mg | $250 | In-stock |
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| Cat. No. : | HY-W019721 |
| M.Wt: | 1216.64 |
| Formula: | C63H113N11O12 |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic;warming;heat to 60°C) |
Cyclosporin D, a metabolite of Cyclosporin A, is a weak immunosuppressant. Cyclosporin D is used as internal standard for quantification of Cyclosporin A[1][2]. Cyclosporin A is a potent immunosuppressant drug, suppress T cell activation by inhibiting calcineurin and the calcineurin-dependent transcription factors nuclear factor of activated T cells (NFAc)[3]. In Vitro: Cyclosporine D inhibits Ca2+/calmodulin dependent EF-2 phosphorylation in vitro[1]. In Vivo: Cyclosporine D is a potent inhibitor in vivo of phorbol ester TPA-induced biological effects in mouse skin[1].
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