Indalpine
CAS No. : 63758-79-2
(Synonyms: LM 5008)
| Size | Price | Stock |
|---|---|---|
| 100mg | $321 | Get quote |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-A0160 |
| M.Wt: | 228.33 |
| Formula: | C15H20N2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Indalpine (LM 5008) is a potent and selective 5-HT uptake blocker. Indalpine is potent in displacing 3H-5-HT bound to brain membranes with the IC50 of 36 μM[1]. Indalpine, two antidepressant agent[2]. In Vivo: In keeping with its potent reuptake-blocking property, acute IV Indalpine produces a marked decrease in the firing rate of dorsal raphe 5-HT neurons (ED50 0.33 mg/kg). The firing rate of dorsal raphe 5-HT neurons is assessed following 2-, 7- and 14-day treatments with Indalpine (5 mg/day IP). After 2 days, the firing rate of 5-HT neurons is greatly reduced, after 7 days it has recovered partially and after 14 days it has returned to normal[2].
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