(R)-Baclofen (hydrochloride)


CAS No. : 63701-55-3

(Synonyms: Arbaclofen (hydrochloride); STX 209 (hydrochloride))

63701-55-3
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Cat. No. : HY-17354A
M.Wt: 250.12
Formula: C10H13Cl2NO2
Purity: >98 %
Solubility: 10 mM in DMSO
Introduction of 63701-55-3 :

(R)-Baclofen hydrochloride (Arbaclofen hydrochloride) is a selective GABAB receptor agonist[1][2]. IC50 & Target: GABAB receptor[1] In Vivo: (R)-Baclofen hydrochloride (STX 209 hydrochloride) suppresses audiogenic seizures in the Fmr1-knockout mouse on the seizure-resistant C57BL/6 background with an effective dose of 1 mg/kg[3].
Acute intraperitoneal administration of (R)-Baclofen hydrochloride significantly reduces the percent of mice displaying seizures (seizure incidence), with a minimum effective dose (MED) of 1.5 mg/kg[3].

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