CAS No. : 63701-55-3
(Synonyms: Arbaclofen (hydrochloride); STX 209 (hydrochloride))
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| Cat. No. : | HY-17354A |
| M.Wt: | 250.12 |
| Formula: | C10H13Cl2NO2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
(R)-Baclofen hydrochloride (Arbaclofen hydrochloride) is a selective GABAB receptor agonist[1][2].
IC50 & Target: GABAB receptor[1]
In Vivo: (R)-Baclofen hydrochloride (STX 209 hydrochloride) suppresses audiogenic seizures in the Fmr1-knockout mouse on the seizure-resistant C57BL/6 background with an effective dose of 1 mg/kg[3].
Acute intraperitoneal administration of (R)-Baclofen hydrochloride significantly reduces the percent of mice displaying seizures (seizure incidence), with a minimum effective dose (MED) of 1.5 mg/kg[3].
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