Pramocaine (hydrochloride)
CAS No. : 637-58-1
(Synonyms: Pramoxine hydrochloride)
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| Cat. No. : | HY-B1319 |
| M.Wt: | 329.86 |
| Formula: | C17H28ClNO3 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic);H2O : 100 mg/mL (ultrasonic) |
Pramocaine (Pramoxine) hydrochloride is a topical surface anesthetic and antipruritic agent. Pramocaine hydrochloride reversibly inhibits voltage-gated sodium channel, reduces transmembrane permeability of sodium ions, stabilizes cell membranes, prevents depolarization, blocks action potential conduction, and inhibits peripheral slow C-fiber pathways associated with pain, pruritus and thermoception. Pramocaine hydrochloride can be used in research related to chronic pruritus, renal pruritus, atopic dermatitis, xerotic pruritus, uremic pruritus, and cutaneous hyperalgesia/pain[1][3].
In Vivo:Pramocaine (7.74-30.96 μmol/kg; intrathecal; single injection) hydrochloride produces dose-dependent spinal sensory and motor block in rats, with ED50 values ranging from 15.47 to 17.77 μmol/kg[2].
Pramocaine (12-120 μmol; s.c.) hydrochloride elicits dose-related cutaneous antinociception in male Sprague-Dawley rats, with an ED50 of 42.1 μmol[3].
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