Estrogen receptor modulator 1
CAS No. : 63676-22-2
| Size | Price | Stock |
|---|---|---|
| 5mg | $30 | In-stock |
| 10mg | $50 | In-stock |
| 25mg | $100 | In-stock |
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| Cat. No. : | HY-110201 |
| M.Wt: | 242.29 |
| Formula: | C14H10O2S |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Estrogen receptor modulator 1 (compound 18) is an orally active and selective estrogen receptor modulator (SERM), with a pIC50 of 0.46. Estrogen receptor modulator 1 induces regression of Tamoxifen-resistant, hormone independent xenograft tumors[1][2].
In Vitro: Estrogen receptor modulator 1 (compound 18) (100 nM; 10 days) inhibits T47D:A18/PKCα and T47D:A18-TAM1 colony formation[2].
Estrogen receptor modulator 1 (100 nM; 9 days) significantly inhibits the growth of MCF-7:5C cell, and induces apoptosis in these cells 6 days[2].
In Vivo: Estrogen receptor modulator 1 (1.5 mg/animal; p.o. ; daily for 2 weeks) results in regression of T47D:A18/PKCα tumors[2].
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