Brofaromine


CAS No. : 63638-91-5

(Synonyms: CGP 11305A)

63638-91-5
Price and Availability of CAS No. : 63638-91-5
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5mg $200 In-stock
10mg $320 In-stock
25mg $520 In-stock
50mg $730 In-stock
100mg $1100 In-stock
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Cat. No. : HY-13339
M.Wt: 310.19
Formula: C14H16BrNO2
Purity: >98 %
Solubility: DMSO : 250 mg/mL (ultrasonic)
Introduction of 63638-91-5 :

Brofaromine (CGP 11305A) is a monoamine oxidase (MAO) inhibitor with IC50 of 0.2?μM for MAO-A. IC50 & Target: IC50: 0.2 ?μM (MAO-A)[1] In Vitro: In order to assess whether the protective effect is related to the inhibition of the MAO-A or due to another mechanism, the effect of Brofaromine (CGP 11305A, BRO) is determined on the activity of MAO-A in cultured cortical cells. It shows, firstly, that cultured cortical cells have a significant MAO-A activity, and secondly, that Brofaromine inhibits the enzyme in a concentration-dependent manner. The IC50 is 0.19?μM for Brofaromine . Hill coefficient is 0.96. The enzyme is almost completely inhibited at 10?μM . Brofaromine inhibits MAO-A activity of our cultured cortical cells in a concentration-dependent manner. The IC50 range of Brofaromine is 0.01?μM to 0.1?μM[1].

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