Niacin (hydrochloride)


CAS No. : 636-79-3

(Synonyms: Nicotinic acid (hydrochloride); Vitamin B3 (hydrochloride))

636-79-3
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Cat. No. : HY-B0143A
M.Wt: 159.57
Formula: C6H6ClNO2
Purity: >98 %
Solubility: 10 mM in DMSO
Introduction of 636-79-3 :

Niacin (Vitamin B3; Nicotinic acid) hydrochloride is an orally active B3 vitamin that is an essential nutrient for humans. Niacin hydrochloride plays a key role in energy metabolism, cell signaling cascades regulating gene expression and apoptosis. Niacin hydrochloride is also used in the study of cardiovascular diseases[1][2]. In Vitro: Niacin hydrochloride (0-900 μM, 42 hours) significantly increases GSH levels and decreases ROS levels, and affects the expression of genes related to apoptosis and lipid metabolism[1].
Niacin hydrochloride (0-40 μM, 24 hours) can inhibit cancer invasive activity at low dose but with no influence on proliferation[2].
In Vivo: Niacin hydrochloride (subcutaneous injection, 3-300 mg/kg, once) can induce vasodilation in a dose-dependent manner within minutes in male C57BL/6 mice[3].

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