Balanol
CAS No. : 63590-19-2
(Synonyms: Ophiocordin; Azepinostatin)
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| Cat. No. : | HY-121197 |
| M.Wt: | 550.51 |
| Formula: | C28H26N2O10 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Balanol (Ophiocordin; Azepinostatin) is a potent and ATP competitive PKC/PKA inhibitor against human PKC isozymes α, β-I, β-II, γ, δ, ε, η (IC50s=4-9 nM) and ζ (IC50=150 nM). Balanol also blocks the phosphorylation of cyclic AMP response element-binding protein (CREB) and myristoylated alanine-rich C kinase substrate (MARCKS). Balanol can be isolated from the fungus Verticillium balanoides[1][2].
In Vitro:Balanol (3 μM; 45 min) inhibits PKA, as inhibiting the induction of luciferase activity by Isoproterenol (HY-B0468) in neonatal rat myocytes A431 cells[1].
Balanol (10 μM; 45 min) inhibits the phosphorylation of CREB and MARCKS in A431 cells[1].
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