Inotuzumab ozogamicin
CAS No. : 635715-01-4
(Synonyms: CMC-544; PF-5208773; WAY-207294)
| Size | Price | Stock |
|---|---|---|
| 100μg | $3000 | Get quote |
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| Cat. No. : | HY-P9959 |
| M.Wt: | 1000.00 |
| Formula: | N/A |
| Purity: | >98 % |
| Solubility: | H2O |
Inotuzumab ozogamicin (CMC-544) is an antibody-targeted chemotherapy agent composed of a humanized anti-CD22 antibody conjugated to Calicheamicin (HY-19609). Inotuzumab ozogamicin and G544 bind human CD22 with similar affinities (Kd ≈ 150 pM). Inotuzumab ozogamicin has demonstrated efficacy against CD22+ B-cell non-Hodgkin’s lymphoma. Inotuzumab ozogamicin can be used in the research of acute lymphoblastic leukemia[1][2][3].
IC50 & Target:Kd ≈ 150 pM (CD22)[1]
In Vitro:Inotuzumab ozogamicin exerts highly potent cytotoxic activity against a vari-
ety of CD22-positive B-cell origin cancer cell lines[1].
Inotuzumab ozogamicin and G544
bind human CD22 with similar affinities (KD ≈ 150 pM)[1].
In Vivo:Inotuzumab ozogamicin causes dose-dependent regression of B-lymphoma xenografts grown as subcutaneous solid tumors in athymic nude mice[1].
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