B7/CD28 interaction inhibitor 1
CAS No. : 635324-72-0
| Size | Price | Stock |
|---|---|---|
| 5mg | $235 | In-stock |
| 10mg | $380 | In-stock |
| 25mg | $700 | In-stock |
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| Cat. No. : | HY-102090 |
| M.Wt: | 427.35 |
| Formula: | C21H13F4N5O |
| Purity: | >98 % |
| Solubility: | DMSO : 62.5 mg/mL (ultrasonic) |
B7/CD28 interaction inhibitor 1 (copmound 6b) is a potent B7.1-CD28 interaction inhibitor with an IC50 of 50 nM[1]. IC50 & Target: IC50: 50 nM (B7.1-CD28 interaction)[1] In Vitro: Bivalent CTLA4 homodimers bridge bivalent B7.1 homodimers to form an unusually stable signaling complex. Blocking B7/CD28 interactions with monoclonal antibodies or soluble receptors results in immunosuppression and enhanced allograft survival, while B7/CTLA-4 blockade results in enhanced antitumor immune responses. The interaction of co-stimulatory molecules on T cells with B7 molecules on antigen presenting cells plays an important role in the activation of naive T cells. Consequently, agents that disrupt these interactions should have applications in treatment of transplant rejection as well as autoimmune diseases[1].
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