Pomaglumetad methionil (anhydrous)
CAS No. : 635318-55-7
(Synonyms: LY2140023)
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| Cat. No. : | HY-14554 |
| M.Wt: | 366.41 |
| Formula: | C12H18N2O7S2 |
| Purity: | >98 % |
| Solubility: |
Pomaglumetad methionil anhydrous (LY2140023) is an orally active, methionine prodrug of the selective mGlu2/3 receptor agonist LY404039. LY2140023 has the potential for schizophrenia research[1][2].
In Vitro:Pomaglumetad methionil (LY2140023) is a high-affinity peptide transporter 1 (PEPT1) substrate with a Km value of ~30 μM[2].
LY2140023 is active against [14C]Gly-Sar with an IC50 value of 0.018 mM[2].
In Vivo:Pomaglumetad methionil (LY2140023; orally; 3-300 mg/kg; once daily for 7 days) dose-dependent increases the levels of the dopamine metabolites dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA)[1].
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- Cat. No.:
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