Pomaglumetad methionil (hydrochloride)


CAS No. : 635318-26-2

(Synonyms: LY2140023 (hydrochloride))

635318-26-2
Price and Availability of CAS No. : 635318-26-2
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1mg $260 In-stock
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25mg $2450 In-stock
50mg $3850 In-stock
100mg $5850 In-stock
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Cat. No. : HY-105040C
M.Wt: 402.87
Formula: C12H19ClN2O7S2
Purity: >98 %
Solubility: DMSO : 25 mg/mL (ultrasonic)
Introduction of 635318-26-2 :

Pomaglumetad methionil hydrochloride (LY2140023 hydrochloride) is an orally active, methionine prodrug of the selective mGlu2/3 receptor agonist LY404039. Pomaglumetad methionil hydrochloride has the potential for schizophrenia research[1][2]. In Vitro: Pomaglumetad methionil (LY2140023) is a high-affinity peptide transporter 1 (PEPT1) substrate with a Km value of ~30 µM[2].
LY2140023 is active against [14C]Gly-Sar with an IC50 value of 0.018 mM[2]. In Vivo: Pomaglumetad methionil (LY2140023; orally; 3-300 mg/kg; once daily for 7 days) dose-dependent increases the levels of the dopamine metabolites dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) [1].

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