L-2-Hydroxyglutaric acid (disodium)
CAS No. : 63512-50-5
(Synonyms: (S)-2-Hydroxyglutaric acid (disodium))
| Size | Price | Stock |
|---|---|---|
| 1g | $29 | In-stock |
| 5g | $137 | In-stock |
| 25g | $480 | In-stock |
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| Cat. No. : | HY-W015114 |
| M.Wt: | 192.08 |
| Formula: | C5H6Na2O5 |
| Purity: | >98 % |
| Solubility: | H2O : 83.33 mg/mL (ultrasonic) |
L-2-Hydroxyglutaric acid disodium is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid disodium can inhibit histone demethylases and hence promote histone methylation[1]. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity with Km and Ki of 2.52 mM and 11.13 mM, respectively[2]. In Vitro: L-2-Hydroxyglutaric acid is potent at inhibiting 2-oxoglutarate (2-OG) dependent dioxygenases (2OGDs) including the Ten Eleven Translocation (TET) enzymes[1].
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