8-pCPT-2′-O-Me-cAMP (sodium)
CAS No. : 634207-53-7
(Synonyms: 8-CPT-2'-O-Me-cAMP (sodium))
| Size | Price | Stock |
|---|---|---|
| 1mg | $170 | In-stock |
| 5mg | $540 | In-stock |
| 10mg | $860 | In-stock |
| 25mg | $1380 | In-stock |
| 50mg | $1794 | In-stock |
| 100mg | $2200 | In-stock |
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| Cat. No. : | HY-107543 |
| M.Wt: | 507.82 |
| Formula: | C17H16ClN5NaO6PS |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic;warming;heat to 60°C) |
8-pCPT-2′-O-Me-cAMP (8-CPT-2'-O-Me-cAMP) sodium, an analog of cAMP, is an activator of exchange proteins activated by cAMP (Epac). 8-pCPT-2′-O-Me-cAMP sodium activates Epac1 (EC50 = 2.2 μM), but not PKA (EC50 >10 μM). 8-pCPT-2′-O-Me-cAMP sodium stimulates Epac-mediated Ca2+ release in pancreatic β-cells in vitro. 8-pCPT-2′-O-Me-cAMP sodium is a Rap1 activator. 8-pCPT-2′-O-Me-cAMP sodium enhances the retinal pigment epithelium barrier against the pathological choroidal endothelial cell invasion that occurs in macular degeneration[1][2][3]. In Vitro:8-CPT-2'-O-Me-cAMP (250 µM; 1 h) sodium induces Rap1 activation and enhances recruitment of junctional proteins and cortical F-actin in retinal pigment epithelium cells[1]. In Vivo:8-CPT-2'-O-Me-cAMP (2.05 µM; 1 µL; intravitreal injection) sodium inhibits development of choroidal neovascular lesions in a laser-injury modl[1].
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