L-902688
CAS No. : 634193-54-7
| Size | Price | Stock |
|---|---|---|
| 11.92 mM * 200 μL in Methanol | $460 | In-stock |
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| Cat. No. : | HY-119163 |
| M.Wt: | 419.47 |
| Formula: | C21H27F2N5O2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
L-902688 is a potent, selective and orally active EP4 receptor agonist with a Ki of 0.38 nM and an EC50 of 0.6 nM. L-902688 shows >4,000-fold selective for EP4 over other EP and prostanoid receptors[1][2]. In Vitro: L-902688 (1 µM; 24 hours; HUVE cells) treatment attenuates TGF-β-induced Twist and α-smooth muscle actin (α-SMA) expression[1]. In Vivo: L-902688 (0.25-1 µg/kg/day; intraperitoneal injection; daily; for 3 weeks; adult male Sprague-Dawley rats) treatment reduces right ventricle fibrosis in the monocrotaline (MCT)-induced PAH rat model[1].
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