SJB2-043
CAS No. : 63388-44-3
| Size | Price | Stock |
|---|---|---|
| 5mg | $60 | In-stock |
| 10mg | $100 | In-stock |
| 25mg | $220 | In-stock |
| 50mg | $350 | In-stock |
| 100mg | $550 | In-stock |
| 200mg | $790 | In-stock |
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| 1 g | Get quote | |
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| Cat. No. : | HY-15757 |
| M.Wt: | 275.26 |
| Formula: | C17H9NO3 |
| Purity: | >98 % |
| Solubility: | DMSO : 3.33 mg/mL (ultrasonic) |
SJB2-043 is an inhibitor of the native USP1/UAF1 complex with IC50 of 544 nM. IC50 & Target: IC50: 544 nM (USP1/UAF1)[1] In Vitro: SJB2-043 causes a dose-dependent decrease in ubiquitin-specific protease 1 (USP1) levels and a concomitant degradation of inhibitor of DNA-binding-1 (ID1) protein in the K562 cells at a micromolar drug concentration. SJB2-043 also causes a decrease in the levels of other ID proteins, namely ID2 and ID3 in K562 cells. SJB2-043 causes a dose-dependent decrease in the number of viable K562 cells, with an EC50 of approximately 1.07 μM. Moreover, SJB2-043 induces apoptosis of K562 cells in a dose-dependent manner[1].
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