Safotibant
CAS No. : 633698-99-4
(Synonyms: LF22-0542)
| Size | Price | Stock |
|---|---|---|
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| 5mg | $285 | Get quote |
| 10mg | $430 | Get quote |
| 25mg | $690 | Get quote |
| 50 mg | Get quote | |
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| Cat. No. : | HY-100827 |
| M.Wt: | 502.63 |
| Formula: | C25H34N4O5S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Safotibant (LF22-0542) is a selective antagonist for kinin B1 receptor (BKB1R), with Ki of 0.35 and 6.5 nM, for human and mouse BKB1R, respectively. Safotibant exhibits analgesic and anti-inflammatory property in mice model[1][2].
In Vivo:Safotibant (10 mg/kg, s.c., 3 times a day for 8 days) exhibits analgesic property against bone cancer-induced pain in osteolytic sarcoma xenograft C3H/HeJ mice model, without affecting disease progression[1].
Safotibant (one eye drop application, twice a day for 7 days) inhibits expressions of inflammatory mediators B1R, iNOS, IL-1β, COX-2, VEGF-R2 and HIF-1α, reverses diabetes-induced retinal inflammation and oxidative stress in streptozotocin (STZ)-diabetic Wistar rats model[2].
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