OUL35
CAS No. : 6336-34-1
(Synonyms: NSC39047)
| Size | Price | Stock |
|---|---|---|
| 5mg | $66 | In-stock |
| 10mg | $110 | In-stock |
| 25mg | $220 | In-stock |
| 50mg | $352 | In-stock |
| 100mg | $550 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-123512 |
| M.Wt: | 256.26 |
| Formula: | C14H12N2O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 83.33 mg/mL (ultrasonic) |
OUL35 (NSC39047) is a potent and selective inhibitor of ARTD10 (PARP-10), with an IC50 of 329 nM[1].
In Vitro: OUL35 rescues HeLa cells from ARTD10-induced cell death and sensitizes cells to DNA damage. OUL35 (3 μM) binds to endogenous ARTD10 in U2OS cells[1].
OUL35 also inhibits ARTD8 (23.4 μM), ARTD4 (22.6 μM), and ARTD15 (4.17 μM) but with modest potency[1].
OUL35 makes hydrogen bonds to the amide and carbonyl of Gly888 and to the side-chain hydroxyl of Ser927. OUL35 stacks between Tyr919 and Tyr932, like 3AB in the crystal structure[1].
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