Azaphen (dihydrochloride monohydrate)

Azaphen (Pipofezin) dihydrochloride monohydrate is an orally active serotonin reuptake inhibitor. Azaphen dihydrochloride monohydrate potentiates sympathomimetic compound effects. Azaphen dihydrochloride monohydrate can be used for the research of depressive states^[1][2]. In Vivo:Azaphen (10-25 mg/kg; single dose) dihydrochloride monohydrate significantly prolongs Phenamine (HY-W016477)-induced stereotypic behavioral reactions in white rats, with mean durations increased to 105 min and 147 min, respectively^[1].
Azaphen (25-50 mg/kg; s.c.; single dose) dihydrochloride monohydrate significantly increases the group toxicity of Phenamine in white mice, inducing up to 95% mortality when combined with 10 mg/kg Phenamine, while also enhancing Phenamine-induced motor activity and hyperthermia^[1].
Azaphen (25-50 mg/kg; s.c.; single dose) dihydrochloride monohydrate antagonizes Reserpine (HY-N0480)-induced depression effects in white mice, reducing blepharoptosis to 2.6 points and 2.3 points, respectively, while decreasing hypothermia^[1].
Azaphen (25-50 mg/kg; s.c.; single dose) dihydrochloride monohydrate antagonizes Tetrabenazine (HY-B0590)-induced depression effects in white mice, reducing blepharoptosis to 2.3 points and 1.1 points, respectively, while decreasing hypothermia and catalepsy^[1].
Azaphen (25 mg/kg; p.o.; single dose) dihydrochloride monohydrate significantly increases active escape attempts in the mouse water escape test, with a mean of 48 water wheel rotations per mouse over 6 minutes^[2].
Azaphen (10-25 mg/kg; p.o.; single dose) dihydrochloride monohydrate exhibits antireserpine activity in mice, with a statistically significant reduction in Reserpine-induced blepharoptosis at 25 mg/kg to a rate of 2.7^[2].
Azaphen (25 mg/kg; p.o.; single dose) dihydrochloride monohydrate significantly reduces anxiety-related inhibition in mice exposed to electric irritation, increasing plate crossings to 10.5 over 2 minutes^[2].
Azaphen (25 mg/kg; p.o.; single dose) dihydrochloride monohydrate significantly reduces aggressive behavior in mice, decreasing fight counts to 8 (isolation-induced) and 9 (electric irritation-induced)^[2].
Azaphen (10 mg/kg; p.o.; single dose) dihydrochloride monohydrate significantly reduces amnesia in rats, increasing passive avoidance conditioned reflex retention to 30% (electroshock-induced) and 50% (Scopolamine (HY-N0296)-induced)^[2].
Azaphen (10 mg/kg; p.o.; daily; 4 days) dihydrochloride monohydrate does not produce a statistically significant restoration of ethanol-impaired active avoidance conditioned reflex learning in rats^[2].
Azaphen (25-100 mg/kg; p.o.; single dose) dihydrochloride monohydrate exhibits dose-dependent antihypoxic activity in mice, significantly increasing survival time in hypoxic hypoxia at 50 mg/kg (37 min) and 100 mg/kg (44 min), and in hemic hypoxia at 25 mg/kg (22 min) and 50 mg/kg (21 min)^[2].
Azaphen (25 mg/kg; p.o.; daily; 5 days) dihydrochloride monohydrate produces a pronounced protective effect in rats with circulatory hypoxia, resulting in 100% survival over 5 days^[2].
Azaphen (5-25 mg/kg; p.o.; single dose) dihydrochloride monohydrate increases physical endurance in mice swimming with a load^[2].
Azaphen (25 mg/kg; p.o.; single dose) dihydrochloride monohydrate does not produce a statistically significant change in mouse motor activity^[2].