Senkyunolide A
CAS No. : 63038-10-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $60 | In-stock |
| 10mg | $100 | In-stock |
| 25mg | $200 | In-stock |
| 50mg | $295 | In-stock |
| 100mg | $430 | In-stock |
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| Cat. No. : | HY-N0743 |
| M.Wt: | 192.26 |
| Formula: | C12H16O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Senkyunolide A is a phthalein compound. Senkyunolide A inhibits the proliferation of tumor cells and has anticancer activity. Senkyunolide A inhibits the progression of osteoarthritis through the NLRP3 signaling pathway. Senkyunolide A protects nerve cells from Corticosterone (HY-B1618) -induced apoptosis by regulating protein phosphatase 2A and α-synuclein signaling pathways. Senkyunolide A inhibits the expression of CD137, a diagnostic biomarker for atherosclerosis[1][2][3][4][5].
In Vitro:Senkyunolide A (0-2.5 μg/mL; 24 h) inhibits the proliferation of HT-29 and CCD-18Co cells with IC50 of 10.4 μM and 20.95 μM, respectively
[1].
Senkyunolide A (100 μM; 6 h) inhibits the high expression of CD137 in TNF-α treated MAECs cells[2].
Senkyunolide A (0.125-0.5 μg/mL; 24-72 h) improves cell viability, decreases apoptosis, LDH release, α-syn expression and PP2P phosphorylation in PC12 cells treated with corticosterone (HY-B1618)[3].
Senkyunolide A (20-80 μg/mL; 48 h) promotes cell proliferation and inhibits cell apoptosis in IL-1β-treated chondrocytes, and inhibits cell inflammation by blocking the NLRP3 signaling pathway[4].
In Vivo:Senkyunolide A (20-40 mg/kg; Intraperitoneal injection; 1 week) shows improvement in the mouse model of osteoarthritis[4].
Pharmacokinetic Analysis in Rats[5]
| Route | Dose (mg/kg) | Tmax (h) | Cmax (mg/L) | t1/2 (h) | AUC0→∞ (mg/h per liter) | Vd/F (L/kg) | CL/F (L/h per kilogram) | F (%) |
| i.v. | 20 (pure) | / | 19.67 | 0.65 | 2.81 | 6.74 | 7.20 | / |
| i.v. | 7.65 (ext)* | / | 4.86 | 0.69 | 0.95 | 7.12 | 9.17 | / |
| i.p. | 50 | 0.04 | 17.60 | 0.67 | 5.29 | 9.98 | 10.92 | 75.3 |
| i.p. | 100 | 0.04 | 31.01 | 0.99 | 10.65 | 13.78 | 9.72 | 75.8 |
| p.o. | 100 | 0.21 | 1.66 | 0.52 | 1.11 | 68.97 | 94.81 | 7.9 |