Trimethylacetaldehyde
CAS No. : 630-19-3
(Synonyms: Pivalic aldehyde; Pivalaldehyde)
| Size | Price | Stock |
|---|---|---|
| 1g | $25 | In-stock |
| 5g | $60 | In-stock |
| 10g | $96 | In-stock |
| 25g | $192 | In-stock |
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| Cat. No. : | HY-Y1668 |
| M.Wt: | 86.13 |
| Formula: | C5H10O |
| Purity: | >98 % |
| Solubility: |
Trimethylacetaldehyde (Pivalic aldehyde; Pivalaldehyde) is an inhibitor of E. coli betaine aldehyde dehydrogenase (ALDH) with a Ki of 4.5 mM. Trimethylacetaldehyde serves as a substrate for Drosophila melanogaster alcohol dehydrogenase (AdhS), undergoing oxidation and disproportionation reactions with the release of NADH, and also forms an inactive binary enzyme-aldehyde complex via a compulsory ordered reaction mechanism[1][2].
In Vitro:Trimethylacetaldehyde (0.5-10 mM) is oxidized by purified Drosophila melanogaster AdhS in a dismutation reaction at pH 9.5 and 23.5 °C, with a Km of 2.4 mM[1].
Trimethylacetaldehyde (100 mM) competitively inhibits purified betaine aldehyde dehydrogenase from Escherichia coli MC4100 (pFF423), with an apparent inhibition constant of 4.5 mM, and reduces the enzyme activity to 11% of that in the control group at a concentration of 100 mM[2].
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