DPPC

DPPC (129Y83) is a phosphoglyceride that can be used to prepare lipid monolayers, bilayers, and liposomes. DPPC is the main lipid component of pulmonary surfactant. Dppc-liposome can be effectively used as a delivery vector to induce an immune response against GSL antigen in mice^{[1][2][3][4][5]}. In Vitro: DPPC (2-10 mg/ml) monolayer can be inserted by Aβ40, but the amount of insertion is smaller than that of DPPG or DPTAP. The behavior of Aβ40 inserted into the DPPC monolayer is affected by surface pressure, solvent (water or PBS), and salt concentration^[3].
DPPC can mix with DPPE to form DPPC/DPPE lipid bilayer systems. As DPPE concentration rises, the average area per headgroup diminishes (0.65 to 0.52 nm²), enhancing membrane compactness. Meanwhile, membrane thickness slightly increases (3.43 to 4.00 nm), reflecting lipid tail ordering. ^[5].
In Vivo: DPPC（0.5 μmol, 7 days) can serve as a critical component that enhances the stability of lipid membrane structures in liposome construction. GSL antigen was virtually non-immunogenic by itself, but GSL antigen-containing DMPC-liposome can enhance the immunogenicity of GSL antigen in mice^[2].