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| Cat. No. : | HY-107372 |
| M.Wt: | 484.14 |
| Formula: | C9H15N2O15P3 |
| Purity: | >98 % |
| Solubility: | H2O : ≥ 150 mg/mL |
Uridine triphosphate (UTP) is a pyrimidine nucleoside triphosphate that is used as a substrate to synthesize RNA or as an energy source in metabolic reactions. Uridine triphosphate activates membrane-bound P2Y2 receptors[1][2].
In Vitro:Uridine triphosphate (UTP) (0, 10, 100, 250, 500, and 1000 µM; 2, 4, 6, 8, 10, and 12 h) enhances RT4-D6P2T cells migration and wound repair. Uridine triphosphate induces Schwannoma cell migration through activation of P2Y2 receptors and through the increase of extracellular MMP-2 activation and expression[2].
Uridine triphosphate (UTP) evokes MAPK phosphorylation in a biphasic pattern MAPK phosphorylation, with an early transient phosphorylation 5 min after treatment, and a late and sustained phosphorylation that appeared at 6 h and lasted up to 24 h[2].
In Vivo:Uridine triphosphate (UTP) (0.44-4.4 µg/kg; i.v.; once) reduces infarct size and improves rat heart function after myocardial infarct[3].
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