Staurosporine (GMP)
CAS No. : 62996-74-1
(Synonyms: Antibiotic AM-2282 (GMP); STS (GMP); AM-2282 (GMP))
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| Cat. No. : | HY-15141G |
| M.Wt: | 466.53 |
| Formula: | C28H26N4O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Staurosporine (AM-2282) (GMP) is Staurosporine (HY-15141) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Staurosporine is a potent, ATP-competitive and non-selective inhibitor of protein kinases[1][2][3][4][5]. In Vitro: Staurosporine (GMP) (316 nM; 24 h) induces the production of robust neurite in RGC-5 cells[1]. Staurosporine (GMP) (25 and 100 nM; 12 h) induces differentiation of SH-SY5Y cells with the increasing of neurite processes combined with a prominent branching and the subsequent reduction in cell body size[2]. Staurosporine (GMP) (20 nM) induces cell differentiation of human neuroblastoma cell line[3]. Staurosporine (GMP) (5 nM) enhances HL-60-cell differentiation induced by 1 alpha,25 dihydroxyvitamin D3, dbc AMP, all-trans-beta-retinoic acid (RA), actinomycin D (Act D) and other compounds[4]. Staurosporine (GMP) (1 μM; 15 d) induces differentiation of human neuroblastoma cells[5].
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