Sapropterin
CAS No. : 62989-33-7
(Synonyms: (6R)-BH4; (6R)-Tetrahydro-L-biopterin)
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| Cat. No. : | HY-A0124 |
| M.Wt: | 241.25 |
| Formula: | C9H15N5O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Sapropterin ((6R)-BH4; (6R)-Tetrahydro-L-biopterin) is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin can be used in study of phenylketonuria (PKU) phenylketonuria. Sapropterin can aggravate experimental autoimmune encephalomyelitis (EAE)[1][2]. In Vitro:Sapropterin enhances residual phenylalanine hydroxylase activity to increase phenylalanine oxidation[1]. In Vivo:Sapropterin (100 mg/kg/day; oral; daily; 22 days) treatment aggravates primary progressive and relapsing-remitting EAE in SJL/J mice, as evidenced by increased clinical EAE scores, elevated plasma long-chain ceramide levels, reduced linolenic acid levels, and increased spinal cord T-cell infiltration[2].
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