AZ-11665362
CAS No. : 629645-40-5
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| Cat. No. : | HY-116811 |
| M.Wt: | 344.41 |
| Formula: | C22H20N2O2 |
| Purity: | >98 % |
| Solubility: |
AZ-11665362 is a CRTh2 (DP2) receptor antagonist with an IC50 of 2.6 nM. AZ-11665362 shows weak activity against aldose reductase, serotonin transporter, CYP 2C19, and CYP 2C9. AZ-11665362 lacks measurable inhibitory activity against COX-1 and COX-2. AZ-11665362 can be used for the research of asthma, and other inflammatory diseases[1].
In Vitro:AZ-11665362 (Compound 12) potently binds to human CRTh2 expressed in HEK 293 cells, with an IC50 of 2.6 nM[1].
AZ-11665362 shows selective activity against rat aldose reductase, serotonin transporter, CYP 2C19, and CYP 2C9 (IC50 values of 150, 2000, 2500 and 5000 μM), with no measurable activity against COX-1 or COX-2 at 3 μM[1].
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