Xanthoangelol


CAS No. : 62949-76-2

62949-76-2
Price and Availability of CAS No. : 62949-76-2
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1mg $150 In-stock
5mg $370 In-stock
10mg $550 In-stock
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Cat. No. : HY-111588
M.Wt: 392.49
Formula: C25H28O4
Purity: >98 %
Solubility: DMSO : 100 mg/mL (ultrasonic)
Introduction of 62949-76-2 :

Xanthoangelol, extracted from Angelica keiskei, suppresses obesity-induced inflammatory responses. Xanthoangelol possesses antibacterial activity. Xanthoangelol inhibits monoamine oxidases. Xanthoangelol induces apoptosis in neuroblastoma and leukemia cells[1][2][3][4]. In Vitro:Xanthoangelol (1 and 5 μM, 24 h) combined with 4-HD suppresses proinflammatory factors, such as NO, TNF-a, and MCP-1 through inhibition of the JNK pathway in the co-culture system of fully differentiated 3T3-L1 adipocytes and RAW264.7 macrophages[1].
Xanthoangelol (1-100 μM, 48 h) reduces the neuroblastoma and leukemia cells survival with cytotoxicity[4].
Xanthoangelol (1-10 μM, 4 h) induces concentration-dependent early apoptosis followed by secondary cell death through activation of caspase-3 in Jurkat cells[4].
In Vivo:Xanthoangelol (0.1% or 0.15% w/w, mixed in a high-fat diet, daily for 14 weeks) suppresses inflammatory mediators in WAT of diet-induced obese mice[1].

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