Mipomersen (sodium)
CAS No. : 629167-92-6
(Synonyms: ISIS 301012)
| Size | Price | Stock |
|---|---|---|
| 1mg | $230 | In-stock |
| 5mg | $584 | In-stock |
| 10mg | $934 | In-stock |
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| Cat. No. : | HY-108764 |
| M.Wt: | 1000.00 |
| Formula: | C230H305N67Na19O122P19S19 |
| Purity: | >98 % |
| Solubility: | H2O : 100 mg/mL (ultrasonic) |
Mipomersen sodium (ISIS 301012) is an antisense oligonucleotide inhibitor of apolipoprotein B (apoB). Mipomersen has anti-HCV effect and reduces the infectivity of the HCV. Mipomersen sodium can be used for the research of homozygous familial hypercholesterolemia (HoFH)[1][2].
In Vitro: Mipomersen predominantly distributes to the liver and decreases the production of apoB-100, the primary structural protein of the atherogenic lipoproteins including low density lipoprotein (LDL), thereby reducing plasma LDL-cholesterol and apoB-100 concentrations[2].
Apolipoprotein (apo) B, a large amphipathic protein, plays a fundamental role in human lipoprotein metabolism. ApoB-100 is also a ligand for LDL receptor-mediated endocytosis of LDL by cells[2].
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